Hon. Prof. PD Dr. med. Dietmar Jacob, MBA Schnitt Jacob
2016
Volle Weiterbildungsermächtigung für die Zusatzbezeichnung Proktologie
 

2015
Chefarzt der Abteilung für Allgemein- und Viszeralchirurgie im St. Marien-Krankenhaus Berlin

2015
Mitglied des Wissenschaftlichen Beirats von Herniamed

2015
Ernennung zum Honorarprofessor an der Medizinischen Fakultät der Universität Pécs für das Fach Chirurgie

2014
Praxiseintritt in den COPV-Berlin

2014
Abschluss des berufsbegleitenden Studiums „Krankenhausmanagement“ an der
Hochschule Neubrandenburg mit dem Master of Business Administration (MBA)

2013 – 2014
Leitender Oberarzt und stellv. Chefarzt am Ev. Krankenhaus Bielefeld,
Klinik für Allgemein- und Viszeralchirurgie,
Leiter Kolorektal- und Minimal Invasiv Chirurgie
(Chefarzt: Prof. Dr. Heise, MBA)

2013
Zusatzbezeichnung Spezielle Viszeralchirurgie (Ärztekammer Münster)

2012
Zusatzbezeichnung Proktologie (Ärztekammer Berlin)

2010 – 2013
Leitender Oberarzt und stellv. Chefarzt am Vivantes Klinikum Spandau,
Klinik für Visceral- und Gefäßchirurgie
(Chefarzt: Prof. Dr. Köckerling)

2009 – 2010
Oberarzt am Vivantes Klinikum Am Urban,
Klinik für Visceral- und Gefäßchirurgie
(Chefarzt: Dr. Raakow)

2008
Habilitation an der Charité für das Fach Chirurgie und Erlangung der Lehrbefugnis
(Chefarzt: Prof. Dr. Neuhaus)

2008
Schwerpunkt Viszeralchirurgie (Ärztekammer Berlin)

2006
Facharzt für Chirurgie (Ärztekammer Berlin)

2004
Assistenzarzt an der Charité Campus Virchow,
Centrum für Muskuloskeletale Chirurgie
(Chefarzt: Prof. Dr. Haas)

2002
Postdoctoral Fellow Dept. of Thoracic & Cardiovascular Surgery,
M.D. Anderson Cancer Center, University of Texas, Houston, USA

2001
Promotion an der Charité
(Chefarzt: Prof. Dr. Neuhaus)

1999 – 2009
Assistenzarzt an der Charité Campus Virchow,
Klinik für Allgemein-, Viszeral- und Transplantationschirurgie
(Chefarzt: Prof. Dr. Neuhaus)

1999
Approbation (Ärztekammer Berlin)

1992 – 1999
Medizinstudium an der FU Berlin und Humboldt Universität zu Berlin

HON. PROF. PD DR. MED. DIETMAR JACOB, MBA

Specialist for surgery, visceral and special visceral surgery, proctologist.


Professor Jacob is an experienced general and abdominal surgeon specializing in the surgical treatment of abdominal wall and inguinal hernias. In addition to traditional conventional methods, his focus is in Minimally Invasive Surgery (MIS) to allow the patient a tissue-sparing and thus pain reduced operation.

Another field of activity as a proctologist is the treatment of ailments and diseases around the sphincter as well as the rectum, such as the hemorrhoid alveoli. Whenever possible, the most recent procedures are applied according to the current guidelines and plastic procedures are also used for the purpose of faster wound healing.

As part of his teaching and lecturing at the Charité and the University of Pécs Professor Jacob takes on major national and international congresses part and thus enables its patients the latest state of scientific knowledge to offer. As part of the quality assurance of COPV voluntarily participates in quality assurance study Herniamed. In all patients with abdominal wall and inguinal hernias an aftercare is performed after 1, 5 and 10 years.

Services

  • Operations of abdominal wall and inguinal hernias (mainly minimally invasive)
  • Treatments of hemorrhoids in painless technique
  • Proctological operations ambulant and stationary
  • Abdominal Surgery

Advanced Qualification

Proctology

Languages:

englisch  Hon. Prof. PD Dr. med. Dietmar Jacob, MBA englisch

 

MEMBERSHIPS


Berufsverband der Deutschen Chirurgen (BDC)
Berliner Chirurgische Gesellschaft (BCG)
Deutsche Gesellschaft für Chirurgie (DGCH)
Deutsche Gesellschaft für Allgemein- und Visceralchirurgie (DGAV)
Deutsche Herniengesellschaft (DHG)
European Hernia Society (EHS)
Chirurgische Arbeitsgemeinschaft für Coloproktologie (CACP)
Chirurgische Arbeitsgemeinschaft für Hernien (CAH)

PUBLICATIONS

ORIGINAL


Köckerling F, Roessing C, Adolf D, Schug-Pass C, Jacob D
Has endoscopic (TEP, TAPP) or open inguinal hernia repair a higher risk of bleeding in patients with coagulopathy or antithrombotic therapy? – Data from the Herniamed Registry.
Surg Endosc 30(5): 2073-81, 2016


Köckerling F, Jacob DA, Wiegank W, Hukauf M, Schug-Pass C, Kuthe A, Bittner R
Endoscopic repair of primary vs recurrent male unilateral inguinals hernias – Are there differences in the outcome?
Surg Endosc 30(3): 1146-55,  2016


Köckerling F, Bittner R, Jacob DA, Schug-Pass C, Seidelmann L, Keller T, Adolf D, Kuthe A
TEP vs TAPP: Comparison of the perioperative outcome in 17,587 patients with a primary unilateral inguinal hernia
Surg Endosc 29(12): 3750-60,  2015


*Jacob DA,* Hackl J, Bittner R, Kraft B, Köckerling F
Perioperative outcome of unilateral versus bilateral inguinal hernia repairs in TAPP technique: analysis of 15,176 cases from the Herniamed Registry.
Surg Endosc. [Epub ahead of print] Mar 2015
*both authors are contributed equally


Köckerling F, Bittner R, Jacob D, Schug-Pass C, Laurenz C, Adolf D, Keller T, Stechemesser B
Do we need antibiotic prophylaxis in endoscopic inguinal hernia repair? – Results of the Herniamed Registry
Surg Endosc. [Epub ahead of print] Mar 2015


Klein F, Jacob DA, Bahra M, Pelzer U, Puhl G, Andreou A, Guel S, Guckelberger O
Prognostic factors for long-term survival in patients with ampullary carcinoma-the results of a 15 year observation period after pancreaticoduodenectomy
Hepatobiliary and Pancreatic Surgery
Hepato-Pancreato-Biliary Surgery (epub) Mar 2014


Köckerling F, von Rosen T, Jacob DA
A new plug repair technique for anal fistula
Frontiers in Surg., doi: 10.3389/fsurg.2014.00017 Mai 2014


*Jacob DA,* Hackl J, Bittner R, Kraft B, Köckerling F
Perioperative outcome of unilateral versus bilateral inguinal hernia repairs in TAPP technique: analysis of 15,176 cases from the Herniamed Registry.
Surg Endosc. [Epub ahead of print] Mar 2015
*both authors are contributed equally


Schug-Pass C, Jacob DA, Lippert H, Köckerling F
Differences in biomechanical stability using various fibrin glue compositions for mesh fixation in endoscopic inguinal hernia repair.
Surgical Endoscopy 26(11): 3282-3286, 2012


*Schug-Pass C, *Jacob DA, Rittinghausen J, Lippert H, Köckerling F
Biomechanical properties of (semi-) synthetic glues for mesh fixation in hernia surgery
Hernia 17(6): 773-777, 2013
*both authors are contributed equally


Köckerling F, Grund S, Jacob DA
Typische intraoperative Komplikationen in der laparoskopischen Chirurgie
Der Chirurg 83(7): 633-641, 2012


Klein F, Bahra M, Glanemann M, Faber W, Warnick P, Andreou A, Gul S, Jacob DA
Matched-pair analysis of postoperative morbidity and mortality for pancreaticogastrostomy and pancreaticojejunostomy using mattress sutures in soft pancreatic tissue remnants
Hepatobiliary Pancreat Dis Int 11(1):89-95, 2012


*Stechemesser B, *Jacob DA, Schug-Paß C, Köckerling F
Herniamed: An internet-based registry for outcome research in hernia surgery
Hernia 16(3): 239-250, 2012
*both authors are contributed equally


Jacob DA, Schug-Paß C, Sommerer F, Tannapfel A, Lippert H, Köckerling F
Comparison of a lightweight polypropylene mesh (Optilene LP) and a large pore knitted PTFE mesh (Infinit) – biocompatibility in a standardized endoscopic extraperitoneal hernia model.
Langenbecks Arch Surg 397(2):283-289, 2012


Jacob DA, Raakow R
Single-port versus multi-port cholecystectomy for acute cholecystitis:
a retrospective comparative analysis
Hepatobiliary Pancreat Dis Int 10(5): 521-525, 2011


Raakow R, Jacob DA
Single-Incision Cholecystectomy in about 200 patients
Minim Invasive Surg
Volume 2011, Article ID 915735, 5 pages doi:10.1155/2011/915735, 2011


Jacob DA, Bahra M, Neuhaus P, Schumacher G
Konservative Therapie multipler Leberabszesse bei Arteria hepatica Verschluss
nach Lebertransplantation
Viszeralmedizin 27(2): 162-165, 2011


Kohler I*, Jacob D*, Budzies J, Lehmann A, Weichert W, Schulz S, Neuhaus P, Röcken C
The phenotypic and genotypic diversity of carcinomas of the papilla of Vater correlate with patient prognosis
Am J Clin Pathol, 135(2): 201-211, 2011
* both authors are contributed equally


Raakow R, Jacob DA
Initial experience in laparoscopic single-port appendectomy:
A pilot study
Dig Surg 28(1): 74-79, 2011


Jacob DA, Raakow R
Transumbilikale single-port Appendektomie:
Erste Ergebnisse und technische Beschreibung.
Zentralbl Chirurgie Apr 6, 2011 [Epub ahead of print]


Jacob DA, Raakow R
Single-port Cholezystektomie: Der neue Standard?
Dtsch Med Wochenschr, 135(27): 1363-1367, 2010


Jacob DA, Haase E, Klein F, Pratschke J, Neumann UP, Neuhaus P, Bahra M
Donor influence on outcome in patients undergoing liver transplantation for PBC
Exp Clin Transplant, 8(2): 104-110, 2010


Jacob DA, Haase N, Lindner T, Haase T
Extraartikuläre rezidivierende Blutung aus dem medialen Retinaculumbereich.
Z Orthop Unfall, 148(5): 579-580, 2010


Glanemann M, Shi B, Liang F, Sun XG, Bahra M, Jacob D, Neumann U, Neuhaus P
Surgical strategies for treatment of malignant pancreatic tumors: extended,
standard or local surgery?
World J Surg Oncol 12;6(1):123, 2008


Bahra M, Jacob D, Langrehr JM, Glanemann M, Schumacher G, Lopez-Hanninen E,
Neuhaus P
Metastatic lesions to the pancreas. When is resection reasonable?
Chirurg 79: 241-248, 2008


Bahra M, Jacob D, Langrehr JM, Neumann UP, Neuhaus P
Carcinoma of the distal and middle bile duct: surgical results, prognostic factors, and long-term follow-up.
J Hepatobiliary Pancreat Surg 15: 501-507, 2008


Jacob DA, Bahra M, Schmidt SC, Schumacher G, Weimann A, Neuhaus P, Neumann UP
Mayo risk score for primary biliary cirrhosis: A useful tool for the prediction of course after liver transplantation?
Ann Transplant, 13: 35-42, 2008


Bahra M*, Jacob DA*, Neumann UP, Langrehr JM, Neuhaus R, Neuhaus P
Influence of donor histology on outcome in patients undergoing transplantation for hepatitis C.
Transplantation, 84(2): 144-148, 2007
* both authors are contributed equally


Jacob DA*, Marcus Bahra*, Jan M Langrehr, Sabine Boas-Knoop, Robert Stefaniak, John Davis, Guido Schumacher, Steffen Lippert, Ulf Neumann
Combination therapy of Poly (ADP-ribose)polymerase inhibitor 3-aminobenzamide and gemcitabine shows strong antitumor activity in pancreatic cancer cells.
Journal of Gastroenterology & Hepatology; 22(5): 738-748, 2007
* both authors are contributed equally


Schumacher G, Hoffmann J, Cramer T, Spinelli A, Jacob D, Bahra M
Antineoplastic activity of 2-methoxyestradiol in human pancreatic and gastric cancer cells with different multidrug-resistant phenotypes.
J Gastroenterol Hepatol 22: 1469-1473, 2007


Bahra M, Jacob D, Thelen A, Neumann UP
Oberbaucheviszeration beim fortgeschrittenen hepatopankreatischen
Chir Gastroenterol 23: 367-373, 2007


Schmidt SC, Hamann S, Langrehr JM, Hoflich C, Mittler J, Jacob D, Neuhaus P
Preoperative high-dose steroid administration attenuates the surgical stress
response following liver resection: results of a prospective randomized study.
J Hepatobiliary Pancreat Surg, 14(5):484-492, 2007


Schmidt SC, Pohle C, Langrehr JM, Schumacher G, Jacob D, Neuhaus P
Laparoscopic-assisted placement of peritoneal dialysis catheters: implantation
technique and results.
J Laparoendosc Adv Surg Tech A, 17(5): 596-599, 2007


Schumacher G., Eisele R, Spinelli A, Schmidt SC, Jacob D, Pratschke J, Neuhaus P
Indications for hand-assisted laparoscopic radiofrequency ablation for liver tumors.
J Laparosendosc Adv Surg Tech A, 17(2): 153-159, 2007


Schumacher G, Weidemann H; Langrehr JM, Jonas S, Mittler J, Jacob D, Schmidt SC, Spinelli A, Pratschke J, Pfitzmann R, Alekseev D, Neuhaus P
Transabdominal ligation of the thoracic duct as treatment of choice for
postoperative chylothorax after esophagectomy
Disease of the esophagus, 20(1): 19-23, 2007


Bahra M, Neumann UP, Jacob D, Langrehr JM, Berg T, Neuhaus R, Neuhaus P
Fibrosis progression in hepatitis C positive liver recipients following sustained virological response to antiviral combination therapy (interferon-ribavirin therapy)
Transplantation, 83(3): 351.-353, 2007


Bahra M, Jacob DA, Pascher A, Plockinger U, Kristiansen G, Neuhaus P, Langrehr JM
Surgical strategies and predictors of outcome for malignant neuroendocrine tumors of the pancreas.
Journal of Gastroenterology & Hepatology, 22(6): 930-935, 2007


Jacob DA, Neumann UP, Bahra M, Langrehr JM, Neuhaus P
Lebertransplantation bei Primär Biliärer Zirhhose:
Retrospektive Analyse eines Zentrums.
Deutsche Medizinische Wochenschrift, 131(42): 2327-2332, 2006


Jacob DA, Bahra M, Langrehr JM
External drainage of pancreatic juice after pancreatic head resection: A comparison between jejunal loop and direct pancreatic duct drainage.
Surgery Today, 36(10): 898-907, 2006


Jacob DA, Neumann UP, Bahra M, Klupp J, Puhl G, Neuhaus R, Langrehr JM
Long-term follow-up after recurrence of primary biliary cirrhosis after liver transplantation in 100 patients.
Clinical Transplantation, 20 (2):211-20, 2006


Lindner T, Bail H, Heise M, Schmidt SC, Jacob D, Haas NP, Stockle U
Traumatic aneurysm of the superior mesenteric artery associated with a burst-fracture of the second lumbar spine – Unforeseen sequelae of a fall from a ladder.
Unfallchirurg, 109(2):160-4, 2006


Jacob D, Schumacher G, Bahra M, Davis J, Zhu H, Zhang L, Teraishi F, Neuhaus P, Fang B
Fiber-modified adenoviral vector expressing the tumor necrosis factor-related apoptosis-inducing ligand gene from the human telomerase reverse transcriptase promoter induces apoptosis in human hepatocellular carcinoma cells.
World Journal of Gastroenterology, 11(17): 2552-2556, 2005


Langrehr JM, Bahra M, Jacob D, Glanemann M, Neuhaus P
Prospective randomized comparison between a new mattress technique and Cattell (duct-to-mucosa) pancreaticojejunostomy for pancreatic resection.
World Journal of Surgery, 29 (9): 1111-1119, 2005


Bahra M, Neumann UP, Jacob D, Langrehr JM, Neuhaus P
Repeated steroid pulse therapies in HCV-positive liver recipients: significant risk factor for HCV-related graft loss.
Transplantation Proceedings, 37(4): 1700-1702, 2005


Jacob DA, Neumann UP, Bahra M, Langrehr JM, Neuhaus P
Liver transplantation for Primary Biliary Cirrhosis: Influence of primary immunosuppression. on survival.
Transplantation Proceedings, 37(4): 1691-1692, 2005


Schumacher G, Oidtmann M, Rueggeberg A, Jacob D, Jonas S, Langrehr JM, Neuhaus R, Bahra M, Neuhaus P
Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth.
World Journal of Gastroenterology, 11(10): 1420-1425, 2005


Loew A, Jacob D, Neuhaus P, Riess H
Resistance to activated protein c caused by factor V Leiden mutation and orthotopic liver transplantation.
Transplantation, 79(10); 1422-1427, 2005


Jacob DA, Davis J, Schumacher G, Bahra M, Neuhaus P, Fang B
Gentherapie durch einen RGD modifizierten, hTERT regulierten, TRAIL exprimierenden adenoviralen Vektor in malignen Tumoren.
Zeitschrift für Gastroenterologie, 42(12):1363-70, 2004


Zhu H, Zhang L, Huang X, Davis JJ, Jacob DA, Teraishi F, Chiao P, Fang B
Overcoming acquired resistance to TRAIL by chemotherapeutic agents and calpain inhibitor I through distinct mechanisms.
Molecular Therapy, 9: 666-673, 2004


Wu S, Zhu H, Gu J, Zhang L, Teraishi F, Davis JJ, Jacob DA, Fang B
Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanol.
Cancer Research, 64: 1110-1113, 2004


Zhang L, Zhu H, Davis JJ, Jacob DA, Wu S, Teraishi F, Gutierrez A, Wang Y, Fang B
Lack of p38 MAP kinase activation in TRAIL-resistant cells is not related to the resistance to TRAIL-mediated cell death.
Cancer Biology & Therapy, 3: 296-301, 2004


Jacob DA, Davis J, Fang B
Xenograftic tumor models in mice for cancer research, a technical review.
Gene Therapy & Molecular Biology, 8: 213-219, 2004


Wu S, Zhu H, Gu J, Zhang L, Teraishi F, Davis JJ, Jacob DA, Fang B
Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanol.
Cancer Research, 64: 1110-1113, 2004


Zhang L, Zhu H, Davis JJ, Jacob DA, Wu S, Teraishi F, Gutierrez A, Wang Y, Fang B
Lack of p38 MAP kinase activation in TRAIL-resistant cells is not related to the resistance to TRAIL-mediated cell death.
Cancer Biology & Therapy, 3: 296-301, 2004


Jacob D, Bahra M, Schumacher G, Neuhaus P, Fang B
Gene therapy of colon cancer cells with a fiber-modified adenovector expressing the TRAIL gene driven by the hTERT promoter.
Anticancer Research, 24(5A): 3075-9, 2004


Zhu H, Zhang L, Wu S, Teraishi F, Davis JJ, Jacob D, Fang B
Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl] amino]ethanol in correlation with activation of ERK.
Oncogene, 23(29): 4984-4992, 2004


Jacob D, Davis J, Zhang L, Zhu H, Teraishi F, Fang B
Suppression of pancreatic tumor growth in the liver by systemic administration of the TRAIL gene driven by the hTERT promoter.
Cancer Gene Therapy, 12(2): 109-115, 2004


Jacob D, Davis J, Zhu H, Zhang L, Teraishi, Wu S, Marini FC, Fang B
Suppressing Orthotopic Pancreatic Tumor Growth with a Fiber modified Adenovector Expressing the TRAIL Gene from the hTERT Promoter.
Clinical Cancer Research, 10: 3535-3541, 2004


Jacob D, Schumacher G, Langrehr JM, Bahra M, Davis J, Marini FC, Neuhaus P und Fang B
Tumorsuppression durch ein RGD modifiziertes, hTERT reguliertes, TRAIL exprimierendes Adenovirus in einem orthotopen Pankreas Tumormodel.
Forumband 33: 123-125, 2004


Bahra M, Neumann UP, Harren M, Jacob D, Langrehr JM, Berg T, Neuhaus R, Neuhaus P
Significance of mycophenolate mofetil treatment in patiens with HCV reinfection after liver transplantation: impact on clinical course and histologic damage.
Transplantation Proceedings: 34: 2934-2935, 2002


Schumacher G, Oidtmann M, Rosewicz S, Langrehr JM, Jonas S, Mueller AR, Rueggeberg A, Neuhaus R, Bahra M, Jacob D, Gerlach H, Neuhaus P
Sirolimus inhibits growth of human hepatoma cells in contrast to tacrolimus which promotes cell growth.
Transplantation Proceedings.;34: 1392-1393, 2002


Walldorf J, Platz KP, Jacob D, Horstmann M, Neuhaus P, Müller AR
sICAM, sVCAM and sE-Selectin May Be Useful Predictors of Postoperative Complications After Major Abdominal Surgery.
5th World Congress on Trauma, Shock, Inflammation and Sepsis,
Editor Eugen Faist, Monduzzi Editore: 431-435, 2000


Jacob D, Müller AR, Walldorf J, Horstmann M, Neuhaus P, Platz KP
IL-8 and IL-10 as Marker for Postoperative Complications after Abdominal surgery.
5th World Congress on Trauma, Shock, Inflammation and Sepsis,
Editor Eugen Faist, Monduzzi Editore: 431-435, 2000
Klein F, Jacob DA, Bahra M, Pelzer U, Puhl G, Andreou A, Guel S, Guckelberger O
Prognostic factors for long-term survival in patients with ampullary carcinoma-the results of a 15 year observation period after pancreaticoduodenectomy
Hepatobiliary and Pancreatic Surgery
Hepato-Pancreato-Biliary Surgery (epub) Mar 2014


Köckerling F, von Rosen T, Jacob DA
A new plug repair technique for anal fistula
Frontiers in Surg., doi: 10.3389/fsurg.2014.00017 Mai 2014


*Jacob DA,* Hackl J, Bittner R, Köckerling F
Uni- versus bilaterale transabdominelle preperitoneal patchplastik in over 10.000 patients. An analysis oft the Herniamed register
Surgical Endoscopy
Under Review
*both authors are contributed equally


*Schug-Pass C, *Jacob DA, Rittinghausen J, Lippert H, Köckerling F
Biomechanical properties of (semi-) synthetic glues for mesh fixation in hernia surgery
Hernia 17(6): 773-777, 2013
*both authors are contributed equally


Schug-Pass C, Jacob DA, Lippert H, Köckerling F
Differences in biomechanical stability using various fibrin glue compositions for mesh fixation in endoscopic inguinal hernia repair.
Surgical Endoscopy 26(11): 3282-3286, 2012


Köckerling F, Grund S, Jacob DA
Typische intraoperative Komplikationen in der laparoskopischen Chirurgie
Der Chirurg 83(7): 633-641, 2012


Klein F, Bahra M, Glanemann M, Faber W, Warnick P, Andreou A, Gul S, Jacob DA
Matched-pair analysis of postoperative morbidity and mortality for pancreaticogastrostomy and pancreaticojejunostomy using mattress sutures in soft pancreatic tissue remnants
Hepatobiliary Pancreat Dis Int 11(1):89-95, 2012


*Stechemesser B, *Jacob DA, Schug-Paß C, Köckerling F
Herniamed: An internet-based registry for outcome research in hernia surgery
Hernia 16(3): 239-250, 2012
*both authors are contributed equally


Jacob DA, Schug-Paß C, Sommerer F, Tannapfel A, Lippert H, Köckerling F
Comparison of a lightweight polypropylene mesh (Optilene LP) and a large pore knitted PTFE mesh (Infinit) – biocompatibility in a standardized endoscopic extraperitoneal hernia model.
Langenbecks Arch Surg 397(2):283-289, 2012


Raakow R, Jacob DA
Single-Incision Cholecystectomy in about 200 patients
Minim Invasive Surg
Volume 2011, Article ID 915735, 5 pages doi:10.1155/2011/915735, 2011


Jacob DA, Raakow R
Single-port versus multi-port cholecystectomy for acute cholecystitis:
a retrospective comparative analysis
Hepatobiliary Pancreat Dis Int 10(5): 521-525, 2011


Jacob DA, Bahra M, Neuhaus P, Schumacher G
Konservative Therapie multipler Leberabszesse bei Arteria hepatica Verschluss
nach Lebertransplantation
Viszeralmedizin 27(2): 162-165, 2011


Kohler I*, Jacob D*, Budzies J, Lehmann A, Weichert W, Schulz S, Neuhaus P, Röcken C
The phenotypic and genotypic diversity of carcinomas of the papilla of Vater correlate with patient prognosis
Am J Clin Pathol, 135(2): 201-211, 2011
* both authors are contributed equally


Raakow R, Jacob DA
Initial experience in laparoscopic single-port appendectomy:
A pilot study
Dig Surg 28(1): 74-79, 2011


Jacob DA, Raakow R
Transumbilikale single-port Appendektomie:
Erste Ergebnisse und technische Beschreibung.
Zentralbl Chirurgie Apr 6, 2011 [Epub ahead of print]


Jacob DA, Raakow R
Single-port Cholezystektomie: Der neue Standard?
Dtsch Med Wochenschr, 135(27): 1363-1367, 2010


Jacob DA, Haase E, Klein F, Pratschke J, Neumann UP, Neuhaus P, Bahra M
Donor influence on outcome in patients undergoing liver transplantation for PBC
Exp Clin Transplant, 8(2): 104-110, 2010


Jacob DA, Haase N, Lindner T, Haase T
Extraartikuläre rezidivierende Blutung aus dem medialen Retinaculumbereich.
Z Orthop Unfall, 148(5): 579-580, 2010


Glanemann M, Shi B, Liang F, Sun XG, Bahra M, Jacob D, Neumann U, Neuhaus P
Surgical strategies for treatment of malignant pancreatic tumors: extended,
standard or local surgery?
World J Surg Oncol 12;6(1):123, 2008


Bahra M, Jacob D, Langrehr JM, Glanemann M, Schumacher G, Lopez-Hanninen E,
Neuhaus P
Metastatic lesions to the pancreas. When is resection reasonable?
Chirurg 79: 241-248, 2008


Bahra M, Jacob D, Langrehr JM, Neumann UP, Neuhaus P
Carcinoma of the distal and middle bile duct: surgical results, prognostic factors, and long-term follow-up.
J Hepatobiliary Pancreat Surg 15: 501-507, 2008


Jacob DA, Bahra M, Schmidt SC, Schumacher G, Weimann A, Neuhaus P, Neumann UP
Mayo risk score for primary biliary cirrhosis: A useful tool for the prediction of course after liver transplantation?
Ann Transplant, 13: 35-42, 2008


Bahra M*, Jacob DA*, Neumann UP, Langrehr JM, Neuhaus R, Neuhaus P
Influence of donor histology on outcome in patients undergoing transplantation for hepatitis C.
Transplantation, 84(2): 144-148, 2007
* both authors are contributed equally


Bahra M*, Jacob DA*, Neumann UP, Langrehr JM, Neuhaus R, Neuhaus P
Influence of donor histology on outcome in patients undergoing transplantation for hepatitis C.
Transplantation, 84(2): 144-148, 2007
* both authors are contributed equally


Jacob DA*, Marcus Bahra*, Jan M Langrehr, Sabine Boas-Knoop, Robert Stefaniak, John Davis, Guido Schumacher, Steffen Lippert, Ulf Neumann
Combination therapy of Poly (ADP-ribose)polymerase inhibitor 3-aminobenzamide and gemcitabine shows strong antitumor activity in pancreatic cancer cells.
Journal of Gastroenterology & Hepatology; 22(5): 738-748, 2007
* both authors are contributed equally


Schumacher G, Hoffmann J, Cramer T, Spinelli A, Jacob D, Bahra M
Antineoplastic activity of 2-methoxyestradiol in human pancreatic and gastric cancer cells with different multidrug-resistant phenotypes.
J Gastroenterol Hepatol 22: 1469-1473, 2007


Bahra M, Jacob D, Thelen A, Neumann UP
Oberbaucheviszeration beim fortgeschrittenen hepatopankreatischen
Chir Gastroenterol 23: 367-373, 2007


Schmidt SC, Hamann S, Langrehr JM, Hoflich C, Mittler J, Jacob D, Neuhaus P
Preoperative high-dose steroid administration attenuates the surgical stress
response following liver resection: results of a prospective randomized study.
J Hepatobiliary Pancreat Surg, 14(5):484-492, 2007


Schmidt SC, Pohle C, Langrehr JM, Schumacher G, Jacob D, Neuhaus P
Laparoscopic-assisted placement of peritoneal dialysis catheters: implantation
technique and results.
J Laparoendosc Adv Surg Tech A, 17(5): 596-599, 2007


Schumacher G., Eisele R, Spinelli A, Schmidt SC, Jacob D, Pratschke J, Neuhaus P
Indications for hand-assisted laparoscopic radiofrequency ablation for liver tumors.
J Laparosendosc Adv Surg Tech A, 17(2): 153-159, 2007


Schumacher G, Weidemann H; Langrehr JM, Jonas S, Mittler J, Jacob D, Schmidt SC, Spinelli A, Pratschke J, Pfitzmann R, Alekseev D, Neuhaus P
Transabdominal ligation of the thoracic duct as treatment of choice for
postoperative chylothorax after esophagectomy
Disease of the esophagus, 20(1): 19-23, 2007


Bahra M, Neumann UP, Jacob D, Langrehr JM, Berg T, Neuhaus R, Neuhaus P
Fibrosis progression in hepatitis C positive liver recipients following sustained virological response to antiviral combination therapy (interferon-ribavirin therapy)
Transplantation, 83(3): 351.-353, 2007


Bahra M, Jacob DA, Pascher A, Plockinger U, Kristiansen G, Neuhaus P, Langrehr JM
Surgical strategies and predictors of outcome for malignant neuroendocrine tumors of the pancreas.
Journal of Gastroenterology & Hepatology, 22(6): 930-935, 2007


Jacob DA, Neumann UP, Bahra M, Langrehr JM, Neuhaus P
Lebertransplantation bei Primär Biliärer Zirhhose:
Retrospektive Analyse eines Zentrums.
Deutsche Medizinische Wochenschrift, 131(42): 2327-2332, 2006


Jacob DA, Bahra M, Langrehr JM
External drainage of pancreatic juice after pancreatic head resection: A comparison between jejunal loop and direct pancreatic duct drainage.
Surgery Today, 36(10): 898-907, 2006


Jacob DA, Neumann UP, Bahra M, Klupp J, Puhl G, Neuhaus R, Langrehr JM
Long-term follow-up after recurrence of primary biliary cirrhosis after liver transplantation in 100 patients.
Clinical Transplantation, 20 (2):211-20, 2006


Lindner T, Bail H, Heise M, Schmidt SC, Jacob D, Haas NP, Stockle U
Traumatic aneurysm of the superior mesenteric artery associated with a burst-fracture of the second lumbar spine – Unforeseen sequelae of a fall from a ladder.
Unfallchirurg, 109(2):160-4, 2006


Jacob D, Schumacher G, Bahra M, Davis J, Zhu H, Zhang L, Teraishi F, Neuhaus P, Fang B
Fiber-modified adenoviral vector expressing the tumor necrosis factor-related apoptosis-inducing ligand gene from the human telomerase reverse transcriptase promoter induces apoptosis in human hepatocellular carcinoma cells.
World Journal of Gastroenterology, 11(17): 2552-2556, 2005


Langrehr JM, Bahra M, Jacob D, Glanemann M, Neuhaus P
Prospective randomized comparison between a new mattress technique and Cattell (duct-to-mucosa) pancreaticojejunostomy for pancreatic resection.
World Journal of Surgery, 29 (9): 1111-1119, 2005


Bahra M, Neumann UP, Jacob D, Langrehr JM, Neuhaus P
Repeated steroid pulse therapies in HCV-positive liver recipients: significant risk factor for HCV-related graft loss.
Transplantation Proceedings, 37(4): 1700-1702, 2005


Jacob DA, Neumann UP, Bahra M, Langrehr JM, Neuhaus P
Liver transplantation for Primary Biliary Cirrhosis: Influence of primary immunosuppression. on survival.
Transplantation Proceedings, 37(4): 1691-1692, 2005


Schumacher G, Oidtmann M, Rueggeberg A, Jacob D, Jonas S, Langrehr JM, Neuhaus R, Bahra M, Neuhaus P
Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth.
World Journal of Gastroenterology, 11(10): 1420-1425, 2005


Loew A, Jacob D, Neuhaus P, Riess H
Resistance to activated protein c caused by factor V Leiden mutation and orthotopic liver transplantation.
Transplantation, 79(10); 1422-1427, 2005


Jacob DA, Davis J, Schumacher G, Bahra M, Neuhaus P, Fang B
Gentherapie durch einen RGD modifizierten, hTERT regulierten, TRAIL exprimierenden adenoviralen Vektor in malignen Tumoren.
Zeitschrift für Gastroenterologie, 42(12):1363-70, 2004


Zhu H, Zhang L, Huang X, Davis JJ, Jacob DA, Teraishi F, Chiao P, Fang B
Overcoming acquired resistance to TRAIL by chemotherapeutic agents and calpain inhibitor I through distinct mechanisms.
Molecular Therapy, 9: 666-673, 2004


Wu S, Zhu H, Gu J, Zhang L, Teraishi F, Davis JJ, Jacob DA, Fang B
Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanol.
Cancer Research, 64: 1110-1113, 2004


Jacob DA, Davis J, Fang B
Xenograftic tumor models in mice for cancer research, a technical review.
Gene Therapy & Molecular Biology, 8: 213-219, 2004


Zhang L, Zhu H, Davis JJ, Jacob DA, Wu S, Teraishi F, Gutierrez A, Wang Y, Fang B
Lack of p38 MAP kinase activation in TRAIL-resistant cells is not related to the resistance to TRAIL-mediated cell death.
Cancer Biology & Therapy, 3: 296-301, 2004


Wu S, Zhu H, Gu J, Zhang L, Teraishi F, Davis JJ, Jacob DA, Fang B
Induction of apoptosis and down-regulation of Bcl-XL in cancer cells by a novel small molecule, 2[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanol.
Cancer Research, 64: 1110-1113, 2004


Zhang L, Zhu H, Davis JJ, Jacob DA, Wu S, Teraishi F, Gutierrez A, Wang Y, Fang B
Lack of p38 MAP kinase activation in TRAIL-resistant cells is not related to the resistance to TRAIL-mediated cell death.
Cancer Biology & Therapy, 3: 296-301, 2004


Jacob D, Bahra M, Schumacher G, Neuhaus P, Fang B
Gene therapy of colon cancer cells with a fiber-modified adenovector expressing the TRAIL gene driven by the hTERT promoter.
Anticancer Research, 24(5A): 3075-9, 2004


Zhu H, Zhang L, Wu S, Teraishi F, Davis JJ, Jacob D, Fang B
Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl] amino]ethanol in correlation with activation of ERK.
Oncogene, 23(29): 4984-4992, 2004


Jacob D, Davis J, Zhang L, Zhu H, Teraishi F, Fang B
Suppression of pancreatic tumor growth in the liver by systemic administration of the TRAIL gene driven by the hTERT promoter.
Cancer Gene Therapy, 12(2): 109-115, 2004


Jacob D, Davis J, Zhu H, Zhang L, Teraishi, Wu S, Marini FC, Fang B
Suppressing Orthotopic Pancreatic Tumor Growth with a Fiber modified Adenovector Expressing the TRAIL Gene from the hTERT Promoter.
Clinical Cancer Research, 10: 3535-3541, 2004


Jacob D, Schumacher G, Langrehr JM, Bahra M, Davis J, Marini FC, Neuhaus P und Fang B
Tumorsuppression durch ein RGD modifiziertes, hTERT reguliertes, TRAIL exprimierendes Adenovirus in einem orthotopen Pankreas Tumormodel.
Forumband 33: 123-125, 2004


Bahra M, Neumann UP, Harren M, Jacob D, Langrehr JM, Berg T, Neuhaus R, Neuhaus P
Significance of mycophenolate mofetil treatment in patiens with HCV reinfection after liver transplantation: impact on clinical course and histologic damage.
Transplantation Proceedings: 34: 2934-2935, 2002


Schumacher G, Oidtmann M, Rosewicz S, Langrehr JM, Jonas S, Mueller AR, Rueggeberg A, Neuhaus R, Bahra M, Jacob D, Gerlach H, Neuhaus P
Sirolimus inhibits growth of human hepatoma cells in contrast to tacrolimus which promotes cell growth.
Transplantation Proceedings.;34: 1392-1393, 2002


Walldorf J, Platz KP, Jacob D, Horstmann M, Neuhaus P, Müller AR
sICAM, sVCAM and sE-Selectin May Be Useful Predictors of Postoperative Complications After Major Abdominal Surgery.
5th World Congress on Trauma, Shock, Inflammation and Sepsis,
Editor Eugen Faist, Monduzzi Editore: 431-435, 2000


Jacob D, Müller AR, Walldorf J, Horstmann M, Neuhaus P, Platz KP
IL-8 and IL-10 as Marker for Postoperative Complications after Abdominal surgery.
5th World Congress on Trauma, Shock, Inflammation and Sepsis,
Editor Eugen Faist, Monduzzi Editore: 431-435, 2000

BOOK CONTRIBUTIONS


Köckerling F, Jacob D, Grund S, Schug-Paß C
Prinzipien der minimalinvasiven Chirurgie bei Hernien Teil 2
Allgemein- und Viszeralchirurgie up2date
Ausgabe 02, Jahrgang 6, April 2012


Köckerling F, Jacob D, Grund S, Schug-Paß C
Prinzipien der minimalinvasiven Chirurgie bei Hernien Teil 1
Allgemein- und Viszeralchirurgie up2date
Ausgabe 02, Jahrgang 6, April 2012


Bahra M und Jacob D
Surgical palliation of advanced pancreatic cancer.
Recent Results Cancer Res, 177:111-20; 2008


Jacob D und Bahra M
Neuroendokrine gastrointestinale Tumoren.
Kapitel: Chirurgische Therapie neuroendokriner Tumoren in Magen, Duodenum und Pankreas.
UNI-MED Science, 1. Auflage 2007
U. Plöckinger (Hrsg.)

LETTER


Köckerling F, Jacob DA, Chowbey P, Lomanto D
Totally extraperitoneal repair of inguinal hernias: some remarks on technical details.
Langenbecks Arch Surg 398(3): 481-482, 2013


Köckerling F, Schug-Pass C, Jacob DA, Keller T
The Intra- and Postoperative Complication Rate of TEP in Patients Undergoing Unilateral Endoscopic Inguinal Hernia Repair Is Not Higher Compared with TAPP
World Journal of Surgery 37(4): 933-934, 2012


Köckerling F, Jacob DA, Bittner R, Chowbey P, Lomanto D, Kukleta J
Risk of postoperative urinary retention after laparoscopic (TAPP) or endoscopic (TEP) inguinal hernia repair
Surg Endoscop
Surgical Endoscopy 27(3): 1049-1050, 2012


Köckerling F, Jacob DA
Classification of surgical meshes and hernia registries
Hernia 16(6): 735-736, 2012


Köckerling F, Jacob DA, Chowbey P, Lomanto D
A meta-analysis examining the use of tacker fixation versus no-fixation of mesh in laparoscopic inguinal hernia repair
International Journal of Surgery 10(6): 325, 2012


Köckerling F, Jacob DA, Lomanto D, Chowbey P
The enhanced view-totally extraperitoneal technique for repair of inguinal hernia
Surgical Endoscopy 26(12): 3691-3692, 2012


Köckerling F, Jacob DA, Lomanto D, Chowbey P
Re: The Endoloop technique for the primary closure of direct inguinal hernia defect during the endoscopic totally extraperitoneal approach
Hernia 16(4): 325, 2012


Köckerling F, Jacob DA
Re: Bilateral total extraperitoneal inguinal hernia repair (TEP) has outcomes similar to those for unilateral TEP: population-based analysis of prospective data of 6,505 patients
Surgical Endoscopy 26(9): 2695-2696, 2012


Köckerling F, Jacob DA, Lomanto D, Chowbey P
Reply to the Letter to the Editor:
„Guidelines for laparoscopic (TAPP) and endoscopic (TEP) treatment of inguinal hernia.“ Surg Endosc 26(8): 2395-2395, 2012


Köckerling F, Jacob DA, Lomanto D, Chowbey C, Bittner R
Re: Slit versus Non-Slit Mesh Placement in Total Extraperitoneal Inguinal Hernia Repair
World J Surg 36(6): 14445-14446, 2012